Betty Joan Duffy Guthrie, also known as “Mawmaw”, 81, of Forest, VA died on Saturday, March 19, 2022 surrounded by her family at UVA hospital in Charlottesville, VA after a long illness. She was born and raised in Keysville, VA on July 2, 1940, a daughter of the late Samuel F. Duffy “Buddy” and Ruth Lindsey Duffy. In addition to her parents, she was preceded in death by a son, Thomas Edward Guthrie, Jr. and a son-in-law, Robert Wayne Hartman. Betty was the loving wife to Thomas Edward “Tom” Guthrie, Sr. for 65 years and spent the first years of their marriage in Brookneal, VA. The family later moved to Richmond, VA until 1973 and at this time moved to Lynchburg, VA to make their forever home. Betty Jo and Thomas raised a family of five children, Jackie Hartman of Lynchburg, Rhonda Miles of Lynchburg, Tina Klacynski (Jay) of Forest, Carol Knowles (Ricky) of Bedford, Thomas Edward Guthrie, Jr. (deceased).  She had several adored grandchildren, Amy Bryant (Steve), Chris Ginther (Christina), Corey Hartman, Brandon Klacynski, Brittany Woody (Ryan), Skylar Rea, Ricky Knowles, Jr., Jarrett Rea (Becca), Braiden Klacynski and Savannah Rea. Betty was blessed with a host of eleven great-grandchildren, Landon Padgett, Taylor and Tyler Bryant, Logan Bryant, Grayson Hartman, Maylin Ginther, Gianna Hartman, Axel Ginther, Brenleigh Woody, Sutton Woody, and Ember Ginther. Betty was a member of Norwood Baptist Church in Forest, VA. She loved the old gospel hymns and played them often at home. The family would like to especially thank UVA hospital, H.T. and Dana Guthrie, Jr., Butch and Teresa Owen, Janice Owen, and Tonda Lee. A funeral service will be held at 11:00 a.m., on Friday, March 25, 2022 at Norwood Baptist Church with Pastor Sam Stump officiating. A graveside service will be held at 2:00 p.m., at Falling River Baptist Church Cemetery 2874 Wickliffe Road, Brookneal, VA. A reception will follow at the home, 1087 Whitney Place, Forest, VA. Family will receive friends from 6:00 – 8:00 p.m., on Thursday, at Norwood Baptist Church. Memorial contributions can be made to Norwood Baptist Church, 1045 Random Way, Forest, VA 24551. Arrangements by Burch-Messier Funeral Home, Bedford, 540-586-7360.